OncoBLAZE
TM

Science
At OncoBlaze, our innovative technology, grounded in peer-reviewed science, enables the delivery of high-dose chemotherapy with pinpoint accuracy to tissues harboring remnant cancer cells after surgery. This drug-device combination pairs a potent chemotherapeutic, encapsulated in heat-sensitive lipid particles, with a precision heating device. Upon mild heating, the lipid particles release the drug directly into targeted tissues. Additionally, our device features an integrated imaging system, allowing real-time visualization of the drug’s precise location and dosage. In preclinical sarcoma mouse models, this approach has shown over 80% efficacy in preventing tumor recurrence.
CONFERENCES AND PRESENTATIONS
Upcoming Presentations
IEEE Engineering in Medicine and Biology Conference 2026
July 26–30, 2026 | Toronto, Canada
World Molecular Imaging Congress 2026
September 8–11, 2026 | Salt Lake City, Utah
Past Presentations
Society for Thermal Medicine 40th Annual Meeting
May 7–9, 2026 | Savannah, Georgia
World Molecular Imaging Congress 2025
September 29–October 3, 2025 | Anchorage, Alaska
Relevant Publications:
AS Mikhail, I Bakhutashvili, WF Pritchard, D Haemmerich, R Hecht, et al.
Frontiers in Pharmacology 17, 1760944, 2026
Review on electrospray nanoparticles for drug delivery: Exploring applications
PR Patel, D Haemmerich
Polymers for Advanced Technologies 35 (7), e6507, 2024
Review of the delivery kinetics of thermosensitive liposomes
D Haemmerich, KK Ramajayam, DA Newton
Cancers 15 (2), 398, 2023
KK Ramajayam, DA Newton, D Haemmerich
International Journal of Hyperthermia 39 (1), 998-1009, 2022
A Motamarry, AM Wolfe, KK Ramajayam, S Pattanaik, T Benton, et al.
Cancers 14 (5), 1322, 2022
Drug transport kinetics of intravascular triggered drug delivery systems
TLM Ten Hagen, MR Dreher, S Zalba, ALB Seynhaeve, M Amin, L Li, et al.
Communications Biology 4 (1), 920, 2021
Untargeted large volume hyperthermia reduces tumor drug uptake from thermosensitive liposomes
KK Ramajayam, AM Wolfe, A Motamarry, GJ Nahhas, J Yost, MJ Yost, et al.
IEEE open journal of engineering in medicine and biology 2, 187-197, 2021
A Motamarry, AH Negussie, C Rossmann, J Small, AM Wolfe, BJ Wood, et al.
International Journal of Hyperthermia 36 (1), 816-825, 2019
C Burke, MR Dreher, AH Negussie, AS Mikhail, P Yarmolenko, A Patel, et al.
International Journal of Hyperthermia 34 (6), 786-794, 2018
Non-invasive image-guided targeted drug delivery
D Haemmerich
The Lancet Oncology 19 (8), 1000-1001, 2018
Thermosensitive liposomes for image-guided drug delivery
D Haemmerich, A Motamarry
Advances in cancer research 139, 121-146, 2018
AL Bredlau, A Motamarry, C Chen, MA McCrackin, K Helke, KE Armeson, et al.
Drug delivery 25 (1), 973-984, 2018
C Rossmann, MA McCrackin, KE Armeson, D Haemmerich
PLoS One 12 (6), e0179131, 2017
A Gasselhuber, MR Dreher, F Rattay, BJ Wood, D Haemmerich
Public Library of Science 7 (10), e47453, 2012
Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: Computational modelling and preliminary in vivo validation
A Gasselhuber, MR Dreher, A Partanen, PS Yarmolenko, D Woods, et al.
International Journal of Hyperthermia 28 (4), 337-348, 2012